Regulation of surfactant protein gene transcription
نویسندگان
چکیده
منابع مشابه
Regulation of lung surfactant protein gene expression.
Surfactant, a complex mixture of lipids and proteins, produced by the alveolar type II cells of the lung epithelium maintains alveolar integrity and plays important roles in the control of host defense and inflammation in the lung. Surfactant protein (SP) A, B, C and D genes are expressed in a cell-type restricted manner by the Clara and/or alveolar type II cells of the lung. Surfactant protein...
متن کاملUnderstanding the regulation of surfactant gene expression.
Among a number of biochemical and morphological criteria, alveolar type-II epithelial cells are defined by the synthesis of surfactant proteins. These molecules are implicated in numerous human diseases such as neonatal respiratory distress syndrome [1] and possibly acute respiratory distress syndrome (ARDS) [2], where a better understanding could lead to new therapeutic modalities via a target...
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Nutrient gene regulation is an important adaptation allowing survival on intermittent food supplies. This adaptative process exists in all species from yeast to mammals. Glucose, the most abundant monosaccharide in nature, provides a very good example of how organisms have developed regulatory mechanisms to cope with a fluctuating level of nutrient supply. In yeast, glucose facilitates its own ...
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In eukaryotic cells, ribosomal RNA (rRNA) gene is transcribed by RNA polymerase I (pol I) in the nucleolus as a large (40 S-47 S) precursor RNA (pre-rRNA) (for reviews, see refs. [1,2]). The mature rRNA species (28 S, 18 S and 5.8 S) are formed after a series of specific endonucleolytic cleavage reactions (for a review, see ref. [3]). The rRNA gene (rDNA) is highly reiterated and is arranged in...
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A new way by which the potency of a eukaryotic transcription factor can be regulated has been discovered, in which nuclear factors increase the concentration of the transcription factor's active form by modulating an otherwise unfavorable equilibrium between monomeric and dimeric forms of the protein.
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 1998
ISSN: 0925-4439
DOI: 10.1016/s0925-4439(98)00076-3